Respiratory System MCQ for RRB & SSC and other Competitive exams
91
Which part of the brain stem sets the basic rhythm of breathing?
RRB/SSC/UPSC
Medium
✓ Answer:
C
Medulla oblongata
The Medulla oblongata contains the primary respiratory control centres that generate the basic rhythm of breathing: Dorsal Respiratory Group (DRG) = stimulates inspiration, generates the basic breathing rhythm, sends signals to diaphragm via phrenic nerve and to external intercostals. Ventral Respiratory Group (VRG) = active during forced breathing, controls both inspiration and expiration during exercise. The Pons modifies the rhythm set by the medulla: Pneumotaxic centre (limits inspiration, prevents over-inflation) and Apneustic centre (prolongs inspiration, promotes deep breaths). Together they ensure smooth, rhythmic breathing.
92
What is a peak flow meter used for?
RRB/SSC/UPSC
Medium
✓ Answer:
B
Measure the maximum speed of air that can be exhaled - used to monitor asthma
A Peak Flow Meter measures the Peak Expiratory Flow Rate (PEFR) - the maximum speed of air that can be expelled from the lungs in a forced exhalation. It is a simple, portable device used primarily to monitor and manage asthma. Normal PEFR: varies by age, sex, height (typically 400-700 L/min in adults). In asthma: PEFR decreases during attacks (bronchoconstriction). Diurnal variation >20% in PEFR is characteristic of asthma. Traffic light system: Green (>80% predicted - good), Amber (50-80% - caution), Red (<50% - emergency). Asthma action plans are based on peak flow readings.
93
What is the term for the movement of oxygen from alveoli into the blood?
RRB/SSC/UPSC
Hard
✓ Answer:
C
Diffusion (down a partial pressure gradient)
Oxygen moves from alveoli into pulmonary capillary blood by simple diffusion - passively moving from an area of high partial pressure to low partial pressure: Alveolar PO2 = ~104 mmHg, Venous blood PO2 = ~40 mmHg, Diffusion gradient = 64 mmHg drives O2 into blood. For efficient diffusion, the alveolar-capillary membrane must be: thin (0.2-0.5 microm), large surface area (~70 m2), good blood flow, and moist. Fick's Law of Diffusion: Rate of diffusion is proportional to (Surface area x Concentration gradient x Solubility) divided by (Thickness x sqrt Molecular weight). CO2 diffuses 20x faster than O2 despite smaller gradient due to higher solubility.
94
What is mesothelioma?
RRB/SSC/UPSC
Hard
✓ Answer:
B
A malignant cancer of the pleura (lining of the lungs) almost exclusively caused by asbestos exposure
Mesothelioma is a rare but aggressive malignant cancer of the mesothelium (the protective lining of organs), most commonly affecting the pleura (pleural mesothelioma). Almost exclusively caused by asbestos exposure - with a latency period of 20-50 years after exposure. Symptoms: progressive breathlessness, pleuritic chest pain, massive pleural effusion, weight loss. Diagnosis: CT scan, pleural biopsy, thoracoscopy. Prognosis: very poor - median survival 12-18 months after diagnosis. India is a major exporter of asbestos - an occupational health concern for construction and textile workers.
95
What happens to the diaphragm during exhalation?
RRB/SSC/UPSC
Medium
✓ Answer:
B
It relaxes and moves upward (domes up) reducing thoracic volume
During exhalation (normal/passive): Diaphragm relaxes and returns to its dome-shaped resting position (moves upward), External intercostals relax (ribs move down and inward), Thoracic volume decreases, intrapulmonary pressure rises above atmospheric pressure, air flows OUT of lungs. During forced exhalation (active - coughing, exercise): Internal intercostal muscles contract (forcefully push ribs down and in) and Abdominal muscles contract (push diaphragm further up), creating very high intrathoracic pressure. This is the exact opposite of inhalation where the diaphragm contracts and flattens downward.
96
What is the condition called when a patient breathes with pursed lips?
RRB/SSC/UPSC
Hard
✓ Answer:
B
Pursed lip breathing - a technique used by COPD patients to slow exhalation and prevent small airway collapse (dynamic airway collapse)
Pursed Lip Breathing (PLB) is a breathing technique where patients exhale slowly through partially closed (pursed) lips - like blowing out a candle gently. In COPD/emphysema, the airways collapse during exhalation (due to loss of elastic tissue support). Pursed lip breathing: Creates back-pressure in the airways during exhalation, Keeps small airways open (prevents dynamic airway collapse), Slows breathing rate, Improves O2 and CO2 exchange, and Reduces air trapping and breathlessness. It is a key component of pulmonary rehabilitation for COPD patients.
97
What is the name of the virus responsible for COVID-19 and how does it affect the respiratory system?
RRB/SSC/UPSC
Medium
✓ Answer:
B
SARS-CoV-2 - causes COVID-19 infection that can lead to severe pneumonia, ARDS, and respiratory failure
COVID-19 is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), first identified in Wuhan, China in 2019. The virus enters cells via the ACE2 receptor (abundant in lung type II pneumocytes). Respiratory effects: Mild (upper respiratory symptoms - cough, loss of smell/taste - anosmia), Moderate (pneumonia - bilateral ground-glass opacities on CT), and Severe (ARDS - Acute Respiratory Distress Syndrome - cytokine storm, respiratory failure, requiring ventilation). Happy hypoxia = Low SpO2 without breathlessness was a key COVID-19 warning sign. Vaccination significantly reduces severe disease and death.
98
What is ARDS (Acute Respiratory Distress Syndrome)?
RRB/SSC/UPSC
Hard
✓ Answer:
B
A life-threatening condition of diffuse lung injury causing severe hypoxaemia, bilateral pulmonary infiltrates, and respiratory failure
ARDS (Acute Respiratory Distress Syndrome) is a life-threatening form of acute lung injury characterised by: Severe hypoxaemia (PaO2/FiO2 ratio <200), Bilateral pulmonary infiltrates on chest X-ray (white-out appearance), Non-cardiogenic pulmonary oedema (not due to heart failure), and Rapid onset (within 1 week of a known trigger). Causes: Sepsis (most common), COVID-19, severe pneumonia, aspiration, trauma, pancreatitis. Mechanism: Massive inflammatory response, damage to alveolar-capillary membrane, fluid leaks into alveoli. Treatment: Lung-protective mechanical ventilation (low tidal volumes), prone positioning, dexamethasone (in COVID-ARDS). Mortality: 30-50%.
99
What is the function of the palatine tonsils?
RRB/SSC/UPSC
Medium
✓ Answer:
B
Lymphoid tissue that traps pathogens entering through the mouth, part of the immune defence
The Palatine Tonsils are masses of lymphoid tissue located in the oropharynx (on either side at the back of the mouth). They are part of Waldeyer's ring (adenoids + palatine tonsils + lingual tonsils). Functions: Trap and filter pathogens (bacteria, viruses) entering through the mouth, and Initiate immune response (contain T and B lymphocytes). Tonsillitis: Common in children - caused by Streptococcus pyogenes (Group A strep) or viral infections. Symptoms: severe sore throat, fever, white patches on tonsils. Treatment: antibiotics (penicillin), tonsillectomy if recurrent. Enlarged tonsils + adenoids can cause obstructive sleep apnoea in children.
100
What is the difference between Type I and Type II pneumocytes (alveolar cells)?
RRB/SSC/UPSC
Hard
✓ Answer:
B
Type I are thin cells covering 95% of alveolar surface for gas exchange; Type II produce surfactant and can regenerate alveolar cells
Alveolar cells (Pneumocytes): Type I Pneumocytes = cover ~95% of alveolar surface area. Extremely thin and flat cells (squamous epithelial) - allow efficient gas diffusion. Cannot divide - vulnerable to injury. Type II Pneumocytes = cover ~5% of alveolar surface (but are more numerous as cells). Produce surfactant (phospholipids - DPPC is the main component). Can divide and differentiate into Type I cells - act as stem cells for alveolar repair after injury. SARS-CoV-2 infects Type II pneumocytes via ACE2 receptors. In NRDS, Type II cells are immature causing insufficient surfactant production.